Computer simulation of granulopoiesis: normal and impaired granulopoiesis.

A computer model simulating granuuse were simulated, resulted in states lopoiesis has been constructed on the resembling cyclical and severe nonbasis of two feedback loops, one concyclical neutropenia, respectively. The trolling the rate of production of granuresults provide evidence that a number locytes at the stem cell level, the other of the periodic features shown by normal controlling the rate of release of granuand abnormal granulopoiesis occur belocytes into the blood. This model recause granulopoiesis is a feedback-conproduced the low-amplitude neutrophil trolled system and suggest that the main oscillation reported in normal individuals assumptions of the model have physical and, when mild and severe marrow failreality.